摘要
目的:研究岷山红三叶草异黄酮对大鼠免疫功能及运动能力的影响.方法:将40 只大鼠随机均分为四组:安静组、安静给药组、运动组和运动给药组,建立递增运动负荷大鼠模型,测量运动大鼠力竭时间、免疫脏器指数、大鼠免疫球蛋白及T淋巴细胞亚群含量.结果:经过6 周的大强度运动,服用岷山红三叶草异黄酮大鼠组与相应的对照组比较,其力竭运动时间明显延长,免疫脏器指数和 T淋巴细胞亚群(CD+4+、CD+8、CD+4/CD+8)、免疫球蛋白(IgA、IgG、IgM)的含量均有明显上升和变化.结论:①岷山红三叶草异黄酮可明显提高大强度耐力训练大鼠力竭运动时间,提高运动能力;②岷山红三叶草异黄酮对运动大鼠的免疫系统产生影响,可以通过调节免疫细胞的功能,增强机体的免疫能力,并且对免疫抑制有一定改善.
Abstract
OBJECTIVE:This study aims to investigate the influence of isorhamnetin derived from Minshan red clover on immune function and exercise capacity in rats.METHODS:Forty rats were randomly divided into four groups:sedentary group,sedentary with isorhamnetin group,exercise group,and exercise with isorhamnetin group.An incremental exercise load rat model was established to measure exhaustion time,immune organ index,immune globulins,and T lymphocyte subpopulations.RESULTS:After 6 weeks of high-intensity exercise,rats treated with isorhamnetin from Minshan red clover exhibited a significant extension in exhaustion time compared to the corresponding control group.Moreover,there were noticeable increases and variations in immune organ index,T lymphocyte subpopulations(CD4+,CD8+,CD4+/CD8+),and immune globulin levels(IgA,IgG,IgM).CONCLUSIONS:(1)Isorhamnetin from Minshan red clover can markedly enhance exhaustion time in rats undergoing high-intensity endurance training,thereby improving exercise capacity.(2)Isorhamnetin from Minshan red clover impacts the immune system in exercised rats by modulating immune cell function,enhancing immune capabilities,and demonstrating some amelioration in immune suppression.
维普
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