目的:探讨体力活动、久坐行为与成年人高尿酸血症(Hyperuricemia,HUA)风险关联及剂量-反应关系,为高尿酸血症的预防提供循证依据.方法:检索PubMed、Cochrane Library、EMbase、Web of Science、中国知网(CNKI)、万方(Wanfang)、中国生物医学文献服务系统(SinoMed)等数据库2023年7月15日前发表的体力活动、久坐行为与高尿酸血症风险关联性的相关文献,运用Cochrane偏倚风险评估工具进行文献质量评价、Stata 15.0软件进行Meta分析和剂量-反应关系Meta分析.研究结果:共纳入13项前瞻性队列研究或病例对照研究,包含750678名受访者,平均随访年限5.9年.风险关系Meta分析结果表明:①MV-PA显著降低成年人发病风险.女性、≥45岁、亚洲人群HUA发病风险可能对MVPA更敏感.②久坐行为显著增加成年人发病风险.男性、≥45岁、欧美人群HUA发病风险可能对久坐行为最敏感.剂量-反应Meta分析发现:①MVPA与HUA发病风险存在负相关非线性剂量-反应关系.MVPA与罹患HUA的风险阈值为15MET-h/w.②久坐行为与HUA存在正相关非线性剂量-反应关系.久坐时间与罹患HUA的风险阈值为25h/w.研究结论:MVPA与HUA存在负相关"对数"剂量-反应关系,久坐行为与HUA存在正相关"指数"剂量-反应关系.
Physical Activity,Sedentary Behavior and Risk Outcomes of Hyperuricemia:A Dose-Response Meta-Analysis
The Objective of this study is to explore the risk association and dose response relationship between physical activity,sedentary behavior and hyperuricemia in adults,and to provide evidence for the prevention of hyperuricemia.Methods:The relevant literature on the correlation between physical activity,sedentary behavior and hyperuricemia risk published before May 31st,2023 in PubMed,Cochrane Library,EMbase,Web of Science,CNKI,Wanfang,SinoMed and other databases was retrieved.The Cochrane bias risk assessment tool was used for literature quality evaluation,and Stata 15.0 software was used for meta-analysis and dose response meta-analysis.Results:A total of 13 prospective cohort study or case-control studies were included,including 750678 respondents,with an average follow-up period of 5.9 years.The meta-analysis of risk relationships showed that:(a)MVPA significantly reduced the risk of developing HUA in adults.Female,over 45 years old,and Asian respondents may be more sensitive to MVPA in terHUA of risk of developing HUA.(b)Long sitting behavior significantly increases the risk of developing HUA in adults.Male,≥45 years old,and European and American populations may be most sensitive to sedentary behavior for the risk of developing HUA.Dose response meta-analysis found that:(a)MVPA is negatively correlated with the risk of HUA onset,and there is a non-linear dose response relationship.The risk threshold for MVPA and developing HUA is 15 MET h/w.(b)There is a positively correlated nonlinear dose-response relationship between sedentary behavior and HUA.The threshold for sedentary time and risk of developing HUA is 25h/w.Conclusion:There is a negative correlation"logarithmic"dose-response relationship between MVPA and HUA,and a positive correlation"exponential"dose-response relationship between sedentary behavior and HUA.
physical activitysedentary behaviorhyperuricemiaadultdose-response Meta
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