Exercise in Maintaining the Body's Barrier Function by AMPK Pathway
Exercise,as a key regulator of human energy metabolism,is closely linked to the integrity of the body's barrier functions.To date,there is limited research on the metabolic pathways through which exercise maintains these barrier functions.In response,this study explains the mechanisms by which appropriate exercise supports the maintenance of key barriers,including the skin barrier,blood-brain barrier,immune barrier,intestinal barrier,and cellular barriers,drawing from rigorous experimental data and real-life case studies.Additionally,the paper reviews domestic and international research on the AMP-activated protein kinase(AMPK)signaling pathway in relation to exercise and its role in preserving barrier functions.The findings indicate that the AMPK pathway,which plays a central role in maintaining barrier integrity,is widely activated in the human body through both single bouts and repeated sessions of exercise.However,excessive exercise may damage barrier integrity.This study aims to elucidate the biological logic by which exercise promotes human health,deepening our understanding of the mechanisms through which scientific exercise benefits the body.It also seeks to inspire greater participation in physical activity,ultimately enhancing the quality of modern life.
exerciseAMPKskin barrierblood-brain barrierimmune barrierintestinal barriercellular barriersmechanism of action
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