The Role and Mechanism of Calcium Homeostasis in the Improvement of Alzheimer's Disease by Exercise
This study reviewed the research progress in understanding the role and mechanism of calcium homeostasis in exercise improving Alzheimer's disease(AD).It is found that calcium homeostasis imbalance is closely related to the occurrence and development of AD,which including multiple aspects such as β-amyloid protein(Aβ)deposition,abnormal phosphorylation of Tau protein,mitochondrial dysfunction,autophagy abnormality,and neuroinflammation.Exercise can regulate calcium homeostasis in body,specifically manifested as regulating the function of calcium ion channels,promoting the release and reuptake of calcium ions in the sarcoplasmic reticulum,and increasing mitochondrial calcium uptake.By regulating calcium homeostasis,exercise reduces Aβ deposition,and the phosphorylation level of Tau protein,improves mitochondrial dysfunction and autophagy abnormality,suppresses neuroinflammation,thereby improving AD.In the future,it is necessary to further explore the molecular mechanism of exercise in regulating calcium homeostasis,and determine the impact of different exercise on different populations.In addition,and study the synergistic effect of exercise and other intervention methods should also be investigated so as to provide new ideas and methods for the prevention and treatment of AD.
calcium homeostasisexerciseAlzheimer's diseaseβ-amyloid proteinTau protein
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