In this paper,the spray atomization technology was used for the humidification-dehumidification desalination,and the Atomization field of humidifier was simulated based on the conservation of mass and energy between droplets and hot air flow.On the basis of assumptions,the droplets evaporation and the heat and mass transfer process in the humidifier was analyzed.As a consequence,the droplets will achieve completely evaporation in 1.29 seconds when the initial air and droplets temperature are 90 ℃ and 20 ℃,the volume ratio of gas and liguid is 45×103,the diameter of droplet is 100 μm,but the diameter will reduce to 36.7 μm and reach equilibrium when the volume ratio of gas and liguid decreases to 40 × 103.Also,the outlet relative-humidity will reach to 100%,outlet humid air temperature is about 35 ℃ and the evaporation can achieve more than 70%,when the volume ratio of gas and liguid is between 25× 103 and 40× 103.This result will provide the theoretical basis to improve the humidifier performance of spray desalination.