This article introduces and analyzes the characteristics of the foundation and structural design of the Central Wastewater Treatment Plant in Panyu District,Guangzhou City.It proposes new ideas on key techni-cal issues such as foundation design,anti-floating design and super-length seamless structure design for large underground wastewater treatment plant.This is beneficial for improving the engineering quality of underground wastewater treatment plant,and it provides valuable references for the construction of other similar projects.