The constraints imposed by karst rock foundations on the bottom slabs of ultra-deep and ultra-long underground structures are greater than those of soil foundations.The installation of anti-floating anchors further increases these constraints,making crack resistance and anti-floating waterproof design more challenging.In this paper,a typical engineering case of ultra-deep and ultra-long underground structures on karst rock founda-tions is introduced and key points of concrete crack control design under high anti-floating water conditions are discussed.It also conducts experiments to verify the effect of the improved sliding layer in reducing the horizon-tal constraints of the rock foundation and obtain the corresponding horizontal resistance coefficient.The results are applied to the crack control design of the Liuguangmen ultra-deep and ultra-long underground sewage treatment plant in Guiyang City,which has a burial depth of over 30 meters and a groundwater level of over 21 meters.The expected goal of structural cracking control is achieved.This study provides reference and guidance for cracking control design of similar future ultra-deep and ultra-long underground structures on karst rock foundations.