Lung cancer is one kind of malignant tumors that seriously threatens human health and life,with the first mortality among all cancers.The present treatment of lung cancer mainly includes surgery,radiation,drugs and immuno-therapy,with the problems such as high cost,strong toxicities or adverse reactions,and limited curative effect.It is neces-sary to constantly find new effective treatments.Previous studies have shown that Nur77,a member of nuclear receptor su-perfamily,plays an important role in the genesis and development of cancer.Furthermore,Nur77 can induce apoptosis of lung cancer cells through its high expression and translocation to mitochondria,which may be a potential target for lung cancer treatment.The current review focus on the drug targets related to lung cancer and Nur77 and its related com-pounds in recent reports,and the trends of future research,which will aid new strategy or theoretical basis for lung can-cer treatment,especially target drug therapy.
NETL
NSTL
万方数据
维普
