Progress on mechanism of cell paraptosis induced by endoplasmic reticulum stress
Paraptosis is a novel programmed cell death characterized by endoplasmic reticulum and mitochondrial swelling and cytoplasmic vacuolization.Studies have shown that endoplasmic reticulum stress(ERS)can not only regulate paraptosis,but also interact with multiple paraptosis signal pathways.This review summarizes the relationship and regula-tory mechanism between ERS and paraptosis.At the same time,it also discusses the unsolved issues in paraptosis,in or-der to explore the specific mechanism of ERS in paraptosis.with a hope to provide theoretical basis and reference for the discovery of paraptosis-related drug targets and drug discovery and development.
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