内质网应激诱导细胞类凋亡的机制研究进展
Progress on mechanism of cell paraptosis induced by endoplasmic reticulum stress
吴瑜婷 1郑雨彤 1石惠萍 1胡琼莹1
作者信息
- 1. 台州学院 医学院,浙江 台州 318000
- 折叠
摘要
类凋亡(paraptosis)是一种新的程序性细胞死亡方式,以内质网和线粒体肿胀、细胞质空泡化为典型特征.有研究表明:内质网应激(endoplasmic reticulum stress,ERS)不仅可以调控类凋亡,还有可能与多种类凋亡信号通路发生作用.文章对内质网应激与类凋亡之间的关系及调控机制进行了综述,并探讨了目前类凋亡研究尚未解决的问题,力求从中探寻内质网应激在类凋亡中的具体作用机制,以期为类凋亡相关的药物作用靶点的发现及药物研发提供理论依据和参考.
Abstract
Paraptosis is a novel programmed cell death characterized by endoplasmic reticulum and mitochondrial swelling and cytoplasmic vacuolization.Studies have shown that endoplasmic reticulum stress(ERS)can not only regulate paraptosis,but also interact with multiple paraptosis signal pathways.This review summarizes the relationship and regula-tory mechanism between ERS and paraptosis.At the same time,it also discusses the unsolved issues in paraptosis,in or-der to explore the specific mechanism of ERS in paraptosis.with a hope to provide theoretical basis and reference for the discovery of paraptosis-related drug targets and drug discovery and development.
关键词
细胞程序性死亡/类凋亡/内质网应激/细胞质空泡化Key words
programmed cell death/paraptosis/endoplasmic reticulum stress/cytoplasmic vacuolization引用本文复制引用
基金项目
浙江省基础公益研究计划(LGF21H280002)
台州市科技计划(工业类)(22gya02)
出版年
2024
NETL
NSTL
万方数据