Aiming at the problems occuring after water flooding,such as intensified reservoir heterogeneity,rapid in-crease of water content,complex distribution of remaining oil,and difficult to improve oil recovery,the study on the influence of low permeability interlayers distribution on the seepage law of positive rhythm heterogeneous reservoirs was conducted.The reservoir numerical simulation software CMG was adopted to simulate the water flooding process of the positive rhythm reservoir with interlayer.At the same time,the sand filling physical model of the positive rhythm heterogeneous reservoir was established based on the similarity criterion,and the water flooding experiment was carried out.Also,the accuracy of the numerical model is verified by the results of physical simulation experi-ments.On this basis,the influence of interlayer position on the seepage law of positive rhythm reservoir is analyzed.The research shows that the existence of interlayer increases the interlayer heterogeneity,plays the role of seepage barrier,and expands the swept volume.After water flooding,the remaining oil in the positive rhythm reservoir would display a distribution pattern featuring"more top and less bottom"under gravitation,which indicates that the area near the interlayer is the main region of remaining oil enrichment.This study is of great significance for further tap-ping the potential of remaining oil and sustainable development of oilfield.