脱落酸生物合成研究进展
Research Progress on Abscisic Acid Biosynthesis
张馨逸1
作者信息
摘要
脱落酸是一种植物激素,能抑制植物生长和增强植物抗逆性,对某些动物疾病也有治疗作用,在农业和医药方面有广泛应用,传统的植物提取法和化学合成法存在成本高、产率低、对原材料依赖高等问题.利用微生物合成脱落酸是一种更经济、便捷的方式.文章以异源合成脱落酸的代谢通路构建方法为重点,对利用酿酒酵母、大肠杆菌、解脂耶氏酵母作为底盘细胞,合成脱落酸的研究和生产应用进行综述与展望.
Abstract
Abscisic acid is a kind of plant hormone,which can inhibit plant growth and enhance plant stress resis-tance.It also has therapeutic effect on some animal diseases,and is widely used in agriculture and medicine.Tradi-tional methods of plant extraction and chemical synthesis suffer from high costs,low yields,and high dependence on raw materials.Utilizing microorganisms for abscisic acid synthesis presents a more economical and convenient approach.This article primarily focuses on the metabolic pathway construction for heterologous synthesis of ab-scisic acid,highlighting the current research and production applications utilizing Saccharomyces cerevisiae,Esch-erichia coli,and Yarrowia lipolytica as chassis cells.
关键词
脱落酸/异源酶表达/酶改造/底盘选择/多模块调谐Key words
Abscisic acid/heterologous enzyme expression/enzyme transformation/selection of chassis cells/multi-module tuning引用本文复制引用
出版年
2024
NETL
NSTL
万方数据