Clinical Application of Abnormal Cerebral Blood Perfusion in Breast Cancer Patients after Chemotherapy
Objective To explore the correlation between the arterial spin labeling and cognitive function of pa-tients with breast cancer after chemotherapy based on arterial spin labeling(ASL)technology.Methods This study prospectively collected 43 female patients with unilateral breast cancer(BC group)confirmed by surgery and pa-thology at Taizhou People's Hospital from January 2020 to December 2022,and all patients received standard chemotherapy after surgery.At the same time,37 healthy control group(HC group)matched in age and educa-tion were recruited.Normal head scan and whole brain ASL scan were performed by Siemens 3.0T magnetic res-onance scanner in both groups,and the value of cerebral blood flow(CBF)in each brain area was statistically ana-lyzed by double-sample t test.Then spearman correlation analysis was used to explore the correlation between CBF value in brain area with blood perfusion difference and neural scale.Results Compared with the healthy control group,the CBF value of the left cerebellar CrusⅡ and bilateral medial temporal gyrus decreased after che-motherapy,and the CBF value of bilateral liliform putamen increased(FWE correction).Correlation analysis showed that CBF values of left cerebellar CrusⅡ area,left middle temporal gyrus and right middle temporal gyrus were positively correlated with neuropsychological scale MMSE(r=0.429,P＜0.01;r=0.413,P＜0.01;r=0.405,P＜0.01).Conclusion There are abnormal cerebral blood perfusion in multiple brain regions and chemotherapy-re-lated cognitive dysfunction in breast cancer patients after chemotherapy.
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