Research advances related to TRP channels and visceral hypersensitivity in inflam-matory bowel disease
Inflammatory bowel disease(IBD)is a common clinical chronic and recurrent inflammatory disease,which is mainly characterized by diffuse intestinal inflammation and visceral sensitivity changes,and has a complex path-ogenesis and etiology.Transient receptor potential(TRP)channel is widely distributed in the gastrointestinal tract,as a multiple stimulus detector,effectors and signal transducers involved in regulating intestinal inflammation and visceral hy-persensitivity(VHS)and promoting or inhibiting it.This review summarized the progress of known major TRP channels and VHS in IBD.
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