间充质干细胞在原发性胆汁性胆管炎中的研究
Study of mesenchymal stem cells in primary biliary cholangitis
曹峥 1申慧琴2
作者信息
- 1. 山西医科大学,山西 太原 030000
- 2. 山西医科大学第二医院消化科
- 折叠
摘要
原发性胆汁性胆管炎是一种慢性自身免疫性胆汁淤积性肝病.近年来研究发现,鉴于间充质干细胞具有免疫调节、抗纤维化和肝细胞分化的特性,正在成为治疗肝脏疾病的新方式,并且越来越多的证据表明间充质干细胞对原发性胆汁性胆管炎的治疗有积极作用.本文从原发性胆汁性胆管炎的发病机制以及间充质干细胞治疗原发性胆汁性胆管炎的作用机制、研究进展等方面展开叙述.间充质干细胞治疗原发性胆汁性胆管炎的前景十分广阔,值得进一步研究.
Abstract
Primary biliary cholangitis(PBC)is a chronic autoimmune cholestatic liver disease.In recent years,studies have found that mesenchymal stem cells(MSCs)are becoming a new way to treat liver diseases due to their characteristics of immune regulation,anti fibrosis and hepatocyte differentiation.More and more evidence shows that MSCs have a positive role in the treatment of PBC.This article reviewed the pathogenesis of PBC,the mechanism of MSCs in the treatment of PBC,and research progress.MSCs have a broad prospect in the treatment of PBC,which is worthy of further study.
关键词
间充质干细胞/原发性胆汁性胆管炎/动物实验/临床研究Key words
Mesenchymal stem cells/Primary biliary cholangitis/Animal experiment/Clinical research引用本文复制引用
出版年
2024
NETL
NSTL
万方数据