摘要
N6-甲基腺苷(N6-methyladenosine,m6A)作为真核生物 RNA中最丰富的表观转录组修饰,通过转移、去除和识别 m6A 甲基化位点来调节 RNA加工、剪接、成核、翻译和稳定性,而这些位点对于肿瘤的发生、进展、代谢和转移至关重要.胰腺癌是一种恶性程度较高的肿瘤,具有诊断晚、转移早、预后差、易耐药、缺乏有效治疗手段等特点,已成为临床治疗的一个巨大挑战.最近有研究发现,m6A修饰异常与胰腺癌的致病机制和恶性进展有关,因此,本文就 m6A 甲基化及其相关调节因子的异常表达在胰腺癌发生发展及治疗中的调控机制作一简要综述,旨在为胰腺癌的改进治疗和开创新疗法提供新思路.
Abstract
As the most abundant apparent transcriptome modification in eukaryotic RNA,N6-methyladenosine(m6A)regulates RNA processing,splicing,nucleation,translation and stability by transferring,removing and identif-ying m6A methylation sites,which are essential for tumorigenesis,progression,metabolism and metastasis.Pancreatic cancer is a highly malignant tumor,which has the characteristics of late diagnosis,early metastasis,poor prognosis,drug resistance and lack of effective treatment,which has become a great challenge to clinical treatment.Recently,it has been found that abnormal m6A modification is related to the pathogenesis and malignant progression of pancreatic cancer.Therefore,this article briefly reviewed the regulatory mechanism of the abnormal expression of m6A methylation and its related regulators in the occurrence,development and treatment of pancreatic cancer,in order to provide new ideas for improved treatment and new treatment of pancreatic cancer.
基金项目
甘肃省非感染性肝病临床医学研究中心(21JR7RA017)
甘肃省消化系统重症疾病临床医学研究中心(21JR10RA017)
NETL
NSTL
万方数据