Meta-analysis of the efficacy and safety of prednisone in combination with azathio-prine in the treatment of autoimmune hepatitis
Objective To evaluate the efficacy and safety of PRED+AZA treatment for autoimmune hepatitis(AIH)through Meta-analysis.Methods Randomised controlled trials of PRED+AZA for AIH in PubMed,EmBase,Cochrane Library,CNKI,CBM,WanFang and VIP databases were searched.The quality of the included literature was evalua-ted.The complete remission rate,biochemical response rate,incidence of adverse events and mortality of patients trea-ted in the literature were extracted and statistically analysed using RevMan 5.3 software.Results A total of 11 publica-tions were included,7 in English and 4 in Chinese.Meta-analysis showed that the control group had a higher rate of complete remission rate for AIH than PRED+AZA group(RR=0.79,95%CI:0.67-0.94,Z=2.69,P<0.05).Sub-group analysis showed no statistically significant difference in complete remission rate for AIH with PRED alone versus PRED+AZA(RR=0.81,95%CI:0.54-1.23,Z=0.97,P>0.05),and higher complete remission rate for AIH with Bude+AZA than PRED+AZA(RR=0.77,95%CI:0.63-0.93,Z=2.71,P<0.05).Compared to the control group,the biochemical remission rate,incidence of adverse events and mortality were not statistically significant(P>0.05).Conclusion The complete remission efficacy of alternative treatments for AIH is superior to that of PRED+AZA,but there are no significant differences in biochemical remission,occurrence of adverse events,or death.The complete re-mission efficacy of PRED alone for the treatment of AIH is comparable to that of PRED+AZA,whereas the complete re-mission efficacy of Bude+AZA for the treatment of AIH is superior to that of PRED+AZA.
NETL
NSTL
万方数据
维普
