The effect of elevated platelet on the prognosis of gastric cancer:a systematic review and Meta-analysis
Objective To explore the predictive value of PLT on the prognosis of gastric cancer patients.Methods The 4 major English databases,PubMed,Embase,Web of Science and the Cochrane Library,were each thoroughly and methodically searched.The literature screening and data extraction process was then carried out by 2 independent reviewers.The processed data we pooled using a random effects model and finally described the combined outcome of OS with HR value and the likelihood of a clinicopathological event with OR value.We also performed overall sensitivity analysis and bias analysis to detect the stability of the study results and the risk of bias.Results For the Meta-analysis,a total of 26 studies involving 21 076 participants underwent screening.The results of the study showed a significant cor-relation between increased PLT and prognosis of gastric cancer(HR=1.41,95%CI:1.24-1.61).The results of sub-group analysis did not affect the overall results.Analysis between clinicopathological features showed that increased PLT were associated with female(OR=1.54,95%CI:1.39-1.70),T stage(OR=2.22,95%CI:1.98-2.49),lymph node metastasis(OR=1.51,95%CI:1.36-1.68),TNM stage(OR=1.84,95%CI:1.60-2.11)and tumor size(OR=2.16,95%CI:1.83-2.56)were associated.Conclusion PLT has a significant predictive value for the prog-nosis of gastric cancer and is associated with advanced clinicopathological stage and high risk of lymph node metastasis.
NETL
NSTL
万方数据
维普
