摘要
胰腺神经内分泌肿瘤(pancreatic neuroendocrine tumor,PanNET)是一种起源于神经内分泌细胞的罕见肿瘤,但近年来其检出率呈逐年升高的趋势.目前治愈性的手术切除是治疗 PanNET 的基石.但尽管经过治愈性的切除,仍有部分患者会在 3 年、5年、10 年后复发.肿瘤大小、肿瘤的功能状态、基于核分裂象计数和 Ki-67 指数的肿瘤分级、淋巴结转移、脉管侵犯、神经侵犯、手术切除边缘状态等已被证实是影响 PanNET术后复发的重要因素.现总结可能影响 PanNET 术后复发的临床病理危险因素,并归纳已经提出的可用于术后监测、随访的预测模型.
Abstract
Pancreatic neuroendocrine tumor(PanNET)is a rare tumor originating from neuroendocrine cells,but its detection rate has been increasing year by year in recent years.Currently,curative surgical resection is the cornerstone of the treatment of PanNET.However,despite curative resection,some patients will relapse after 3,5 and 10 years.Tumor size,functional status of the tumor,tumor grade based on mitotic count and Ki-67 index,lymph node metastasis,vascular invasion,nerve invasion and marginal status of surgical resection have been proven to be important factors af-fecting postoperative recurrence of PanNET.This article would summarize the clinicopathological risk factors that may af-fect postoperative recurrence of PanNET,and the proposed prediction models that can be used for postoperative monito-ring and follow-up.
NETL
NSTL
维普
万方数据