Clinical and pathological risk factors for postoperative recurrence of curable pancre-atic neuroendocrine tumor
Pancreatic neuroendocrine tumor(PanNET)is a rare tumor originating from neuroendocrine cells,but its detection rate has been increasing year by year in recent years.Currently,curative surgical resection is the cornerstone of the treatment of PanNET.However,despite curative resection,some patients will relapse after 3,5 and 10 years.Tumor size,functional status of the tumor,tumor grade based on mitotic count and Ki-67 index,lymph node metastasis,vascular invasion,nerve invasion and marginal status of surgical resection have been proven to be important factors af-fecting postoperative recurrence of PanNET.This article would summarize the clinicopathological risk factors that may af-fect postoperative recurrence of PanNET,and the proposed prediction models that can be used for postoperative monito-ring and follow-up.