Effect of probiotic therapy on eradication of different types of H.pylori on gastrin-17 and pepsinogen
Objective To investigate the effect of the different types of H.pylori eradication combined with probiotic on gastrin-17(G-17)and pepsinogen(PG).Methods A total of 116 patients with H.pylori positive chronic gastritis were randomly divided into quadruple therapy group and combination probiotic therapy group.The course of treatment was 2 weeks.One hundred healthy people with positive H.pylori were selected as the healthy control group.Serum H.pylori-specific antibodies CagA,VacA,UreA and UreB were detected.The serum levels of PG Ⅰ,PG Ⅱ,PG Ⅰ/PG Ⅱ ratio(PGR)and G-17 were detected before and after treatment.Results The prevalence of H.pylori type Ⅰwas significantly higher than that of H.pylori type Ⅱ in the three groups(P＜0.05).The prevalences of H.pylori type I in two therapy groups were significantly higher than those in the healthy control group each(P＜0.05).The prevalence of CagA+VacA antibody was higher than that of CagA and VacA antibody in each group(P＜0.05).The prevalences of VacA,UreA and UreB antibodies were higher than that of CagA antibody in each group(P＜0.05).There were no sig-nificant differences in the prevalence of CagA and UreB antibody in chronic gastritis of different inflammatory degrees(P＞0.05).Compared with mild chronic gastritis group,the prevalence of VacA antibody in severe chronic gastritis group was increased significantly,while the prevalence of UreA antibody was decreased significantly(P＜0.05).Com-pared with H.pylori type Ⅱ infected persons,the levels of PG Ⅱ and G-17 in H.pylori type Ⅰ infected persons in each group increased significantly,and the PGR decreased significantly(P＜0.05),while the level of PG Ⅰ had no signifi-cant difference before treatment(P＞0.05).After the eradication of H.pylori,the levels of PG Ⅰ,PG Ⅱ and G-17 in H.pylori type Ⅰ patients in the combination probiotic therapy group decreased significantly,and the PGR increased(P＜0.05).Conclusion H.pylori type Ⅰ strain is the main pathogenic strain of chronic gastritis,and affects the lev-els of serum PG Ⅰ,PG Ⅱ,PGR and G-17 in patients.Combination probiotic therapy can significantly reduce the level of serum PG Ⅰ,PG Ⅱ,G-17,and increase the levels of serum PGR in patients with chronic gastritis of H.pylori type Ⅰ.
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