非酒精性脂肪性肝病与幽门螺杆菌感染关系的探讨
The relationship between non-alcoholic fatty liver disease and Helicobacter pylori infection
方颖 1金家东 1黄冬波 1朱新宇 1周达1
作者信息
- 1. 复旦大学附属中山医院消化科,上海 200032
- 折叠
摘要
目的 探讨H.pylori感染与非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)之间的相关性.方法 收集2022年1月至2022年10月就诊于我院消化科门诊,行13C呼气试验,完成腹部超声检查并有完整血生化结果的289例患者的数据.应用Logistic 回归性分析H.pylori感染与NAFLD的相关性.结果 H.pylori阳性组NAFLD患病率显著高于H.pylori阴性组,分别为 46.8％(58/124)和 29.1％(48/165)(P=0.002).NAFLD 组 H.pylori 感染率明显高于非 NAFLD 组,分别为 54.7％(58/106)和36.1％(66/183)(P=0.002).在H.pylori感染患者中,NALFD患者和非NAFLD患者的13C呼气试验的BOD值分别为29.5± 2.65和34.3±2.46,差异无统计学意义(P=0.1885).在NAFLD患者和非NAFLD患者中,H.pylori阳性组和阴性组之间的各项血生化指标差异均无统计学意义(P＞0.05).多因素Logistic回归分析结果显示,H.pylori感染者较H.pylori非感染者患NAFLD风险更大,差异有统计学意义(P=0.001).结论 H.pylori感染者更易发生NAFLD,H.pylori感染是NAFLD的独立危险因素;反之,NAFLD患者有更高的H.pylori感染率,两者存在一定的相关性.
Abstract
Objective To investigate the relationship between H.pylori infection and non-alcoholic fatty liver disease(NAFLD).Methods A total of 289 patients were encountered in our hospital from Jan.2022 to Oct.2022,and 13C-UBT,abdominal ultrasound examination,liver function,renal function,blood glucose and blood lipids were ob-tained.Logistic analysis was used to analyze the correlation between H.pylori infection and NAFLD.Results The prev-alence of NAFLD in H.pylori positive group(46.8％,58/124)was significantly higher than that in H.pylori negative group(29.1％,48/165)(P=0.002).The H.pylori infection rate in NAFLD group(54.7％,58/106)was higher than that in non-NAFLD group(36.1％,66/183)(P=0.002).In patients with H.pylori infection,the BOD values of 13C-UBT in NALFD patients and non-NAFLD patients were 29.5±2.65 and 34.3±2.46,respectively,with no statistical difference(P=0.1885).In NAFLD patients and non-NAFLD patients,there was no significant difference in liver func-tion,renal function,blood glucose and blood lipids between H.pylori positive group and negative group(P＞0.05).Multivariate Logistic regression analysis showed that the risk of NAFLD in H.pylori infected patients was higher than that in H.pylori non-infected patients,with statistical difference(P=0.001).Conclusion H.pylori infected patients are more likely to develop NAFLD.H.pylori infection is an independent risk factor for NAFLD.NAFLD patients have a higher H.pylori infection rate,and there may be a correlation between H.pylori infection and NAFLD.
关键词
幽门螺杆菌/非酒精性脂肪性肝病/相关性Key words
Helicobacter pylori/Non-alcoholic fatty liver disease/Relevance引用本文复制引用
基金项目
上海市自然科学基金(22ZR1460800)
国家自然科学基金青年基金(81800510)
上海市青年科技英才"扬帆计划"项目(18YF1415900)
出版年
2024
NETL
NSTL
万方数据