调节性T细胞在肝细胞癌患者外周血中的表达及临床意义
Expression and clinical significance of regulatory T cells in peripheral blood of pa-tients with hepatocellular carcinoma
费睿成 1郭彩茹 2亓民3
作者信息
- 1. 新乡医学院,河南新乡 453000;郑州大学附属洛阳中心医院老年医学科
- 2. 洛阳市肝癌个体化治疗重点实验室
- 3. 郑州大学附属洛阳中心医院老年医学科
- 折叠
摘要
目的 探讨在不同病理分期肝细胞癌(hepatocellular carcinoma,HCC)患者外周血中CD4+CD25+CD127LOW Treg的含量变化及临床意义.方法 收集60例HCC患者的外周抗凝血作为HCC试验组并进行Edmondson-steiner病理分期,20名健康体检者的外周抗凝血作为健康对照组,检测两组CD4+CD25+CD127LOW Treg水平.结果 HCC患者外周血中Treg占CD4+T细胞的百分率显著高于健康对照组(P＜0.01);且在HCC不同分期中,Ⅲ、Ⅳ期患者外周血中Treg占CD4+T细胞的百分率显著高于Ⅰ、Ⅱ期患者(P＜0.05).结论 在HCC患者外周血中,Treg随着疾病的发生发展而逐渐增多,且在Ⅲ、Ⅳ期快速增殖,其可能与肿瘤细胞免疫逃逸密切相关.
Abstract
Objective To investigate the changes and clinical significance of CD4+CD25+CD127LOW Treg in periph-eral blood of patients with hepatocellular carcinoma(HCC)at different pathological stages.Methods A total of 60 ca-ses of HCC patients with peripheral anticoagulation were collected as the experimental group and Edmondson-steiner pathological staging,20 cases of healthy examiners with peripheral anticoagulation were collected as the healthy control group.Levels of CD4+CD25+CD127LOW Treg in two groups were detected.Results The percentage of Treg in CD4+T cells in peripheral blood of patients with HCC was significantly higher than that of healthy control group(P＜0.01).In different stages of HCC,the percentage of Treg in CD4+T cells in peripheral blood of patients with stage Ⅲ and Ⅳ was significantly higher than that of patients with stage Ⅰ and Ⅱ(P＜0.05).Conclusion In the peripheral blood of HCC patients,Treg cells gradually increase with the development of the disease,and proliferate rapidly in stage Ⅲ and Ⅳ,which may be closely related to tumor cell immune escape.
关键词
肝细胞癌/调节性T淋巴细胞/流式细胞术/外周血/临床意义Key words
Hepatocellular carcinoma/Regulatory T cells/Flow cytometry/Peripheral blood/Clinical significance引用本文复制引用
基金项目
洛阳市公益性行业医疗卫生专项(2302008A)
出版年
2024
NETL
NSTL
万方数据