Expression and clinical significance of regulatory T cells in peripheral blood of pa-tients with hepatocellular carcinoma
Objective To investigate the changes and clinical significance of CD4+CD25+CD127LOW Treg in periph-eral blood of patients with hepatocellular carcinoma(HCC)at different pathological stages.Methods A total of 60 ca-ses of HCC patients with peripheral anticoagulation were collected as the experimental group and Edmondson-steiner pathological staging,20 cases of healthy examiners with peripheral anticoagulation were collected as the healthy control group.Levels of CD4+CD25+CD127LOW Treg in two groups were detected.Results The percentage of Treg in CD4+T cells in peripheral blood of patients with HCC was significantly higher than that of healthy control group(P＜0.01).In different stages of HCC,the percentage of Treg in CD4+T cells in peripheral blood of patients with stage Ⅲ and Ⅳ was significantly higher than that of patients with stage Ⅰ and Ⅱ(P＜0.05).Conclusion In the peripheral blood of HCC patients,Treg cells gradually increase with the development of the disease,and proliferate rapidly in stage Ⅲ and Ⅳ,which may be closely related to tumor cell immune escape.
Hepatocellular carcinomaRegulatory T cellsFlow cytometryPeripheral bloodClinical significance
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