Research progress of photodynamic therapy combined with immune check-point inhibitors in the treatment of gastrointestinal tumors
Immune checkpoint inhibitors(ICIs)have been gradually developed in the treatment of gastrointestinal tumors.ICIs activate the host anti-tumor response by blocking the immunosuppressive interaction between immune cells and tumor cells.However,only a subset of patients can benefit from ICIs.In recent years,photodynamic therapy(PDT)has developed into a new means of tumor treatment,which can kill tumor cells by producing reactive oxygen species,induce immunogenic cell death,and promote cytotoxic T cell infiltration.However,the immune response in-duced by PDT is generally weak.Therefore,PDT combined with ICIs has the advantage of enhancing anti-tumor im-mune response and reducing tumor metastasis and recurrence.This article reviewed the recent studies on PDT combined with ICIs in the treatment of gastrointestinal tumors,providing new insights and ways for the treatment of gastrointestinal tumors.
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