Expression and significance of P21-activated kinase 4 in gastrointestinal stromal tumor
Objective To explore the relationship between P21-activated kinase 4(PAK4)and the risk of gastroin-testinal stromal tumor(GIST),and to study the expression of PAK4 in GIST with different risk grade.Methods From Oct.2020 to Apr.2021,24 inpatients with GIST in the First Hospital of Qinhuangdao were selected.According to the risk grading evaluation method,the patients were divided into high-risk group,medium-risk group and low-risk group.The expressions of PAK4 in different risk groups were determined by pathological sections,and according to Callow cal-culation method.Results The expression PAK4 increased with the risk escalation of GIST,and the expression of PAK4 in GIST was higher than that in normal control tissues and adjacent tissues.Conclusion The expression level of PAK4 is related to the risk of GIST,and the expression level increases with the increase of the risk.
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