糖尿病患者合并胃食管反流病危险因素的Meta分析
Risk factors of gastroesophageal reflux disease in diabetes patients:a Meta-analysis
陆雅蓉 1贾婧 1李祎玮 1熊观瀛1
作者信息
- 1. 南京医科大学第二附属医院消化医学中心,江苏 南京 210011
- 折叠
摘要
目的 探讨糖尿病患者合并胃食管反流病(gastroesophageal reflux disease,GERD)的危险因素,为糖尿病患者防治 GERD提供参考.方法 计算机检索 Cochrane Library、PubMed、Web of Science、中国知网、万方数据库、维普数据库,收集建库以来关于糖尿病合并 GERD危险因素的病例对照研究,并运用纽卡斯尔-渥太华量表(Newcastle-Ottawa scale,NOS)对文献质量进行评价,纳入评分≥7 分的文献.结果 最终纳入 12 篇文献,累计糖尿病患者 3 007 例.Meta分析显示,性别(OR=0.82,95%CI:0.68～0.99)、周围神经病变(OR=1.63,95%CI:1.05～2.51)、自主神经病变(OR=2.31,95%CI:1.21～4.42)是糖尿病患者合并 GERD 的危险因素.敏感性分析和发表偏倚结果显示,各因素合并结果稳定性良好,无明显的发表偏倚.结论 性别、周围神经病变、自主神经病变是糖尿病合并 GERD的危险因素,建议有危险因素的糖尿病患者定期进行 GERD的筛查.
Abstract
Objective To explore the risk factors of gastroesophageal reflux disease(GERD)in diabetes patients by Meta-analysis,and to provide a reference for the prevention of GERD in diabetes patients.Methods Cochrane Library,PubMed,Web of Science,CNKI,WanFang Database and VIP were searched to collect case-control studies on risk fac-tors of GERD in diabetes mellitus.The Newcastle-Ottawa scale(NOS)was used to evaluate the quality of the literature,and the literature with a score≥7 points was included.Results Twelve studies involving 3 007 diabetes patients were included.Meta-analysis indicated that gender(OR=0.82,95%CI:0.68-0.99),peripheral neuropathy(OR=1.63,95%CI:1.05-2.51),autonomic neuropathy(OR=2.31,95%CI:1.21-4.42)were risk factors for GERD in diabe-tes patients.Sensitivity analysis and publication bias results revealed that the combined results of each factor were sta-ble,and there was no obvious publication bias.Conclusion Gender,peripheral neuropathy and autonomic neuropathy are the risk factors of GERD in diabetes patients.It is suggested that diabetes patients with risk factors should be regu-larly screened for GERD.
关键词
糖尿病/胃食管反流病/危险因素/Meta分析Key words
Diabetes/Gastroesophageal reflux disease/Risk factors/Meta-analysis引用本文复制引用
出版年
2024
NETL
NSTL
万方数据