炎症性肠病患者微量元素锌、硒缺乏患病率的Meta分析
Prevalence of zinc and selenium deficiency in patients with inflammatory bowel dis-ease:a Meta-analysis
杨梦娇 1张梦 1袁浩 2郑亚 2王玉平 2郭庆红2
作者信息
- 1. 兰州大学第一临床医学院,甘肃 兰州 730000;兰州大学第一医院消化科;甘肃省消化疾病临床研究中心
- 2. 兰州大学第一医院消化科;甘肃省消化疾病临床研究中心
- 折叠
摘要
目的 系统评价炎症性肠病(inflammatory bowel disease,IBD)患者微量元素锌、硒缺乏患病率.方法 计算机检索知网、万方、维普、PubMed、EmBase及 Cochrane Library数据库,搜集包含 IBD 患者微量元素锌、硒缺乏患病率的临床研究,检索时限均从建库至 2022 年 11 月 9 日.两名评审员通过阅读全文独立地筛选需要纳入的文献,提取资料并评价纳入研究的偏倚风险后,采用Stata 15.1 软件进行 Meta分析.结果 共纳入 14 项研究,包括 2 915 例 IBD 患者.Meta 分析结果显示,IBD 患者锌缺乏总患病率为 29%(95%CI:21%～37%),硒缺乏总患病率为 10%(95%CI:7%～14%).根据疾病类型进行亚组分析结果显示:溃疡性结肠炎(ulcerative colitis,UC)患者锌缺乏患病率为 23%(95%CI:13%～34%),硒缺乏患病率为 7%(95%CI:4%～10%);克罗恩病(Crohn's disease,CD)患者锌缺乏患病率为 34%(95%CI:23%～45%),硒缺乏患病率为 14%(95%CI:10%～18%).结论 IBD 患者微量元素锌、硒缺乏总患病率较高,且 CD患者锌、硒缺乏患病率均高于 UC患者.
Abstract
Objective To systematically review the prevalence of zinc and selenium deficiency in patients with inflamma-tory bowel disease(IBD).Methods The CNKI,WanFang Data,VIP,PubMed,EmBase and The Cochrane Library data-bases were electronically searched to collect studies on the prevalence of zinc and selenium deficiency in patients with IBD from inception to Nov.9th,2022.Two reviewers independently screened the literature by reading the full text,extracted data and assessed the risk of bias of the included studies.Meta-analysis was then performed using Stata 15.1 software.Results A total of 14 studies involving 2 915 IBD patients were included.The Meta-analysis results showed that the prevalence of zinc deficiency was 29%(95%CI:21%-37%),and the prevalence of selenium deficiency was 10%(95%CI:7%-14%)in IBD patients.Subgroup analysis according to disease types showed that the prevalence of zinc deficiency was 23%(95%CI:13%-34%),and the prevalence of selenium deficiency was 7%(95%CI:4%-10%)in patients with ulcerative colitis(UC).The prevalence of zinc deficiency was 34%(95%CI:23%-45%).and the prev-alence of selenium deficiency in patients with CD was 14%(95%CI:10%-18%)in patients with Crohn's disease(CD).Conclusion The total prevalence of zinc and selenium deficiency in IBD patients is high,and the prevalence of zinc and selenium deficiency in CD patients is higher than that in UC patients.
关键词
炎症性肠病/锌缺乏/硒缺乏/患病率/Meta分析Key words
Inflammatory bowel disease/Zinc deficiency/Selenium deficiency/Prevalence/Meta-analysis引用本文复制引用
基金项目
甘肃省自然科学基金(21JR1RA117)
甘肃省自然科学基金(20JR5RA347)
兰州大学第一医院院内项目(ldyyyn2019-28)
兰州大学第一医院院内项目(ldyyyn2018-54)
出版年
2024
NETL
NSTL
万方数据