Clinical value of serum prealbumin and retinol-binding protein in patients with cirrhosis complicated with liver cancer
Objective To investigate the clinical value of serum prealbumin(PA)and retinol-binding protein(RBP)in patients with cirrhosis and cirrhosis complicated with liver cancer.Methods The clinical data of 428 pa-tients with cirrhosis admitted to the Affiliated Hospital of Southwest Medical University from Jan.2022 to Sep.2022 were collected.At the same time,patients with cirrhosis were grouped according to Child-Pugh grading,model for end stage liver disease(MELD)score,and whether the admission was complicated with liver cancer.Serum PA and RBP levels were measured.The correlation between the two indexes and liver reserve function in patients with cirrhosis and cirrhosis complicated with liver cancer was analyzed.Results The levels of serum PA and RBP in Child-Pugh-A grade were the highest,and the levels of serum PA and RBP in Child-Pugh-C grade were the lowest.With the increase of Child-Pugh grade,the levels of serum PA and RBP were gradually decreased(P<0.05).Serum PA and RBP levels in low MELD group were significantly higher than those in high MELD group(P<0.05).The levels of serum PA and RBP in patients with cirrhosis complicated with liver cancer were significantly higher than those in non-liver cancer group(P<0.05).Spearman correlation test showed that serum PA and RBP levels were negatively correlated with Child-Pugh grading and MELD score in patients with cirrhosis(r<0,P<0.05),and serum PA levels were also negatively correlated with the occurrence of liver cancer(r<0,P<0.05).Conclusion Serum PA and RBP can sensitively reflect the dam-age of liver function,evaluate the function of residual hepatocytes in patients with cirrhosis,and PA can predict the oc-currence of liver cancer to a certain extent.
CirrhosisPrealbuminRetinol-binding proteinLiver cancer
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