Predictive effect of Ranson score combined with PCT in acute pancreatitis compli-cated by acute kidney injury
Objective To investigate the predictive value of Ranson score combined with procalcitonin(PCT)in se-vere acute pancreatitis(SAP)complicated by acute kidney injury(AKI),in order to offer clinical treatment refer-ences.Methods This retrospective analysis included 238 SAP patients hospitalized in the Affiliated Hospital of Xuzhou Medical University from Jan.2020 to Dec.2022.Based on whether AKI occurred at 7 d of admission,238 SAP patients were divided into AKI group(n=72,30.38%)and non-AKI group(n=166,69.62%).The clinical data of all pa-tients were collected through the electronic medical record system.and the risk factors for secondary AKI in SAP pa-tients were analyzed using multifactor Logistic regression.The performance of each score and PCT in predicting secondary AKI in SAP patients was assessed using the ROC curve method,and the results were expressed as AUC.Results In AKI group,central venous pressure,red blood cell distribution width,IL-6,PCT,proportion of surgical treatment,SOFA,BISAP and Ranson scores were significantly higher than those in the non-AKI group(P<0.05).Multifactor Logistic regression analysis identified central venous pressure>11 mmHg,PCT>6.30 ng/ml,and BISAP>4.50 points were risk factors for secondary AKI in SAP patients.ROC curves demonstrated that the Ranson score combined with PCT had the highest efficacy in predicting AKI in SAP patients,with an AUC of 0.835(95%CI:0.797-0.903).Conclusion The Ranson score and PCT are correlated with AKI occurrence in SAP,and their combined application predicts the risk of secondary AKI in SAP patients aiding in the screening and identification of high-risk groups.
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