Research progress on the role of gut microbiota in gallstone disease and its preven-tion and treatment
The function of the gallbladder is to concentrate and store bile.The precursor of its main component,bile acids,is cholesterol.Excessive cholesterol secretion or reduced bile acid synthesis will lead to cholesterol supersatura-tion and gallstone formation.Recently,it has been found that patients with cholelithiasis have gut microbiota dysbiosis,which is involved in bile acid metabolism.Its relationship with cholelithiasis has attracted widespread attention.In this regard,this article discussed the impact of intestinal flora and its metabolites on cholelithiasis,and ways to target the regulation of intestinal flora to prevent and treat cholelithiasis.
Gut microbiotaCholelithiasisBile acidCholecystectomy
NETL
NSTL
万方数据
