肠道菌群在胆石症及其防治中作用的研究进展
Research progress on the role of gut microbiota in gallstone disease and its preven-tion and treatment
范妙言 1崔梦妍 1赵梦琦 1江巧丽 1陆颖影1
作者信息
- 1. 上海交通大学医学院附属第一人民医院消化科,上海 201620
- 折叠
摘要
胆囊的功能为浓缩和储存胆汁,其主要成分胆汁酸的前体为胆固醇,胆固醇分泌过多或胆汁酸合成减少将导致胆固醇过饱和,形成胆石.近来发现胆石症患者存在肠道菌群失调,而肠道菌群参与胆汁酸代谢,因此其与胆石症的关系已引起广泛关注.本文讨论了肠道菌群及其代谢产物对胆石症的影响,以及以调整肠道菌群为靶点防治胆石症的方法.
Abstract
The function of the gallbladder is to concentrate and store bile.The precursor of its main component,bile acids,is cholesterol.Excessive cholesterol secretion or reduced bile acid synthesis will lead to cholesterol supersatura-tion and gallstone formation.Recently,it has been found that patients with cholelithiasis have gut microbiota dysbiosis,which is involved in bile acid metabolism.Its relationship with cholelithiasis has attracted widespread attention.In this regard,this article discussed the impact of intestinal flora and its metabolites on cholelithiasis,and ways to target the regulation of intestinal flora to prevent and treat cholelithiasis.
关键词
肠道菌群/胆结石/胆汁酸/胆囊切除术Key words
Gut microbiota/Cholelithiasis/Bile acid/Cholecystectomy引用本文复制引用
基金项目
上海市嘉定区医学重点学科建设项目(第五批)(2020-jdyxzdxk-15)
出版年
2024
NETL
NSTL
万方数据