Research progress in tryptophan kynurenine metabolism,immune cells,and inflam-matory bowel disease
Inflammatory bowel disease(IBD)is a global disease,which still cannot be eradicated,the burden of disease is increasing.Immune cells such as T cells,DC cells,NK cells,macrophages and ILC cells play an important role in IBD.Tryptophan kynurenine metabolic pathway products can regulate the replication,function and apoptosis of immune cells in a variety of ways,thus participating in the occurrence and development of IBD.This review described the role of multiple immune cells in IBD and the mechanism of tryptophan and kynurenine pathway participating in IBD by regulating immune cells,which can provide theoretical basis for biological treatment of IBD and targeted drug re-search of IBD,and provide better treatment for patients with IBD.
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