Research progress on non-alcoholic fatty liver disease in cell and animal models
Non-alcoholic fatty liver disease(NAFLD)is a clinical syndrome characterized by fatty deposition of the liver and closely associated with metabolic disorders,excluding alcohol and other liver damaging factors,including sim-ple steatohepatitis(SFL),non-alcoholic steatohepatitis(NASH),and subsequent cirrhosis.Epidemiological statistics indicate that the prevalence of NAFLD is increasing year by year in China,and NAFLD has become the most common chronic liver disease in China.Some NAFLD patients can progress to NASH,and NASH can further develop into hepa-tocellular carcinoma(HCC),which is the main cause of HCC.China has a large population base,and the resulting medical and economic burden should not be underestimated.Research on NAFLD is inseparable from the construction of models.A better model means more reliable research results.However,there is no unified model for modeling NAFLD.In this paper,existing cell and animal NAFLD models were reviewed,including model construction methods,and ani-mal NAFLD models induced by various dietary patterns were compared,aiming to provide guidance for researchers to se-lect and construct appropriate NAFLD models.
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