壶腹部神经内分泌肿瘤的研究进展
Research progress of ampullary neuroendocrine neoplasm
陈银泽 1宋晶 2刘小敏 2孙逊 3孟祥伟2
作者信息
- 1. 河南省胸科医院 郑州大学附属胸科医院消化内科,河南 郑州 450008
- 2. 吉林大学第一医院胃肠内科
- 3. 吉林大学第一医院病理科
- 折叠
摘要
壶腹部神经内分泌肿瘤(ampullary neuroendocrine neoplasm,A-NEN)发病率低、分类复杂且临床病理特点多样.随着A-NEN报道数量的增加,研究者对本病的认识正在不断深化.然而,由于一些临床工作者对 A-NEN 的认识存在不足,使得部分患者未能获得最佳的诊治.A-NEN发病初期的临床表现不典型,许多患者发现时已处于进展期.提高 A-NEN 的早期诊断率、明确A-NET的内镜治疗指征,以及寻找更有效的抗肿瘤治疗靶点是目前研究的重点.本文以各种类型 A-NEN 的临床病理特征为出发点,对诊断及治疗的相关进展进行综述,为 A-NEN患者的个体化治疗提供参考依据.
Abstract
Ampullary neuroendocrine neoplasm(A-NEN)has low incidence,complex classification and various clinicopathological features.As more cases of A-NEN are being reported,researchers' understanding of disease is deepe-ning.However,many patients failed to get the best diagnosis and treatment due to the lack of understanding of the dis-ease by clinicians.The clinical manifestations in the early stage of A-NEN are not typical,and some patients are already in the progressive stage when they are diagnosed.Improving the early diagnosis rate of A-NEN,defining the endoscopic treatment indications of A-NET and finding more effective anti-tumor therapy targets are the focus of the current re-search.Based on the clinicopathological features of various types of A-NEN,this article reviewed the progress of diagno-sis and treatment,to provide reference for individualized treatment of A-NEN patients.
关键词
肝胰管壶腹/神经内分泌肿瘤/临床病理特点/诊断/治疗Key words
Ampulla of vater/Neuroendocrine neoplasm/Clinicopathological characteristics/Diagnosis/Treatment引用本文复制引用
出版年
2024
NETL
NSTL
万方数据