Research progress of ampullary neuroendocrine neoplasm
Ampullary neuroendocrine neoplasm(A-NEN)has low incidence,complex classification and various clinicopathological features.As more cases of A-NEN are being reported,researchers' understanding of disease is deepe-ning.However,many patients failed to get the best diagnosis and treatment due to the lack of understanding of the dis-ease by clinicians.The clinical manifestations in the early stage of A-NEN are not typical,and some patients are already in the progressive stage when they are diagnosed.Improving the early diagnosis rate of A-NEN,defining the endoscopic treatment indications of A-NET and finding more effective anti-tumor therapy targets are the focus of the current re-search.Based on the clinicopathological features of various types of A-NEN,this article reviewed the progress of diagno-sis and treatment,to provide reference for individualized treatment of A-NEN patients.
Ampulla of vaterNeuroendocrine neoplasmClinicopathological characteristicsDiagnosisTreatment
NETL
NSTL
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