Effect of virulence gene sequence variation on the virulence of Helicobacter pylori
H.pylori is a prevalent bacterium,known to elevate the risk of gastric cancer when present in the body.Approximately 50%of the global population was infected with H.pylori.However,only about 2 to 3 percent of people infected with H.pylori eventually develop gastric cancer.The diverse disease outcomes are influenced by intricate inter-actions among bacterial,host and environmental factors.Advances in understanding of H.pylori pathogenesis has im-proved over the past 20 years through studies of host and bacterial factors.These studies have unveiled the impact of va-rious virulence factor sequence variations on H.pylori pathogenicity and their associations with different disease manifes-tations,particularly focusing on bacterial adhesins,cytotoxins and vacuolar toxins.
Helicobacter pyloriVirluence geneSequence variationGastric cancer
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