毒力基因序列变异对幽门螺杆菌毒力的影响
Effect of virulence gene sequence variation on the virulence of Helicobacter pylori
王萌萌 1梁淑贞 2余梦超 2王莉莉 2王啸宇 2董全江2
作者信息
- 1. 山东第二医科大学临床医学院,山东 潍坊 261000;青岛市市立医院中心实验室
- 2. 青岛市市立医院中心实验室
- 折叠
摘要
幽门螺杆菌(Helicobacter pylori,H.pylori)是一种常见细菌,H.pylori感染已经被证实为胃癌的高危因素.世界上约 50%人口感染了 H.pylori.然而,最终只有 2%～3%的 H.pylori感染者会患上胃癌.不同的疾病结局是由细菌、宿主和环境因素之间复杂的相互作用所介导的.过去 20 年里,通过对宿主和细菌因素的研究,提高了对 H.pylori发病机制的认识.这些研究包括确定不同的毒力因子序列变异对 H.pylori致病的影响及其与不同疾病结局的关联,特别是细菌黏附素、细胞毒素和空泡毒素等.
Abstract
H.pylori is a prevalent bacterium,known to elevate the risk of gastric cancer when present in the body.Approximately 50%of the global population was infected with H.pylori.However,only about 2 to 3 percent of people infected with H.pylori eventually develop gastric cancer.The diverse disease outcomes are influenced by intricate inter-actions among bacterial,host and environmental factors.Advances in understanding of H.pylori pathogenesis has im-proved over the past 20 years through studies of host and bacterial factors.These studies have unveiled the impact of va-rious virulence factor sequence variations on H.pylori pathogenicity and their associations with different disease manifes-tations,particularly focusing on bacterial adhesins,cytotoxins and vacuolar toxins.
关键词
幽门螺杆菌/毒力基因/序列变异/胃癌Key words
Helicobacter pylori/Virluence gene/Sequence variation/Gastric cancer引用本文复制引用
出版年
2024
NETL
NSTL
万方数据