幽门螺杆菌与小肠细菌过度生长的相关性研究
The association of Helicobacter pylori infection and small intestinal bacterial overgrowth
刘茜 1崔立红1
作者信息
- 1. 南方医科大学第二临床医学院,广东 广州 510280;中国人民解放军总医院第六医学中心消化内科
- 折叠
摘要
我国人口感染 H.pylori的人数占一半以上,其感染与多种消化系统疾病有关,且可产生大量的毒力因子,诱导胃肠道炎症反应、增加消化道肿瘤风险,并对胃肠道菌群产生不利影响.小肠细菌过度生长(small intestinal bacterial overgrowth,SIBO)是由小肠内细菌过多引起的表现为一系列胃肠道不适的临床综合征,其病因复杂,在肠易激综合征、炎症性肠病、肝病、胰腺炎等多种消化系统疾病中有较高的阳性率.本文针对 H.pylori感染及治疗对 SIBO 的可能影响及其相关机制作出综述,并阐述了益生菌对于铋四联疗法根除 H.pylori后肠道菌群的调节作用.目前对合并 H.pylori感染及 SIBO的人群治疗方案尚无定论,本文将对其治疗方案进行讨论.
Abstract
More than half of the population in our country is infected with H.pylori,which is associated with a varie-ty of digestive system diseases and can produce a large number of virulence factors,inducing gastrointestinal inflamma-tion,increasing the risk of gastrointestinal tumors,and adversely affecting gastrointestinal microbiota.Small intestinal bacterial overgrowth(SIBO)is a clinical syndrome with a series of gastrointestinal symptoms caused by excessive bacte-ria in the small intestine,with complex etiology and a high positive rate in irritable bowel syndrome,inflammatory bowel disease,liver disease,pancreatitis and other digestive diseases.This article reviewed the possible effects of H.pylori in-fection and treatment on SIBO and its related mechanisms,and illustrated the regulatory effect of probiotics on intestinal microbiota after bismuth quadruple eradication therapy.The treatment of the population with both H.pylori infection and SIBO is inconclusive and will be discussed here.
关键词
幽门螺杆菌感染/小肠细菌过度生长/益生菌/胃肠道菌群/铋四联疗法Key words
Helicobacter pylori infection/Small intestinal bacterial overgrowth/Probiotics/Gastrointestinal micro-biota/Bismuth quadruple therapy引用本文复制引用
基金项目
首都卫生发展科研专项(首发2020-2-5113)
出版年
2024
NETL
NSTL
万方数据