Correlation between Helicobacter pylori colonization intensity and different degrees of chronic gastritis
Objective To explore the correlation between the colonization intensity of H.pylori and the severity,ac-tivity intensity,and histopathological changes of chronic gastritis.Methods A retrospective analysis of medical records of patients who underwent gastroscopy at Dongfang Hospital,Beijing University of Chinese Medicine from Jun.2021 to Feb.2023 was conducted.According to the results of pathological examination,patients were divided into groups of mild,moderate,and severe H.pylori colonization,and the differences in gender,severity of chronic gastritis,activity intensity of chronic gastritis,and histopathological changes among the three groups were analyzed.Results There was no statistically significant difference in gender and H.pylori colonization intensity(P=0.481).The activity intensity of chronic gastritis increased with the increase of H.pylori colonization intensity(P<0.001).The severity of chronic gas-tritis increased with the increase of H.pylori colonization intensity(P<0.001).With the increase of H.pylori coloniza-tion degree,the possibility of formation of lymphoid follicles,interstitial congestion,mucosal erosion,mucosal ulcera-tion,and intestinal metaplasia increased(P<0.05).Conclusion The increase in H.pylori colonization intensity may exacerbate chronic gastritis,and reducing H.pylori colonization should be considered as a health goal.
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