血UA及Cys C水平与胃癌患者临床病理特征间的关系分析
Analysis of the relationship between serum UA and Cys C levels and clinicopatholog-ical characteristics of gastric cancer patients
肖华 1樊潇潇 1朱炳喜2
作者信息
- 1. 徐州医科大学,江苏 徐州 221000
- 2. 徐州医科大学附属医院消化内科
- 折叠
摘要
目的 研究血尿酸(uric acid,UA)及胱抑素C(cystatin C,Cys C)水平与胃癌患者临床病理的关系.方法 选取徐州医科大学附属医院普外科行胃癌根治术的患者 220 例作为胃癌组,以同期在该院体检的 204 名健康人群为健康对照组,分析两组 UA 及Cys C水平差异,以及临床病理资料与UA、Cys C水平之间的相关性.结果 胃癌组UA及Cys C水平显著高于健康对照组.UA升高组与 UA降低组、Cys C 升高组与 Cys C 降低组,在淋巴结转移、神经或脉管浸润、分化程度、TNM 分期差异有统计学意义(P<0.05).UA升高+Cys C升高组胃癌患者的淋巴结转移率明显高于UA降低+Cys C升高组、UA降低+Cys C降低组,差异有统计学意义(P<0.001).UA与 Cys C呈中度正相关(r=0.534,P<0.001).结论 胃癌患者UA与Cys C水平升高,提示分化程度越低、更易淋巴结转移及神经或脉管浸润、TNM 分期越晚,预后越差.
Abstract
Objective To study the relationship between serum uric acid(UA)and cystatin C(Cys C)levels and the clinicopathology of patients with gastric cancer.Methods A total of 220 patients who underwent radical surgery for gastric cancer in the Department of General Surgery,the Affiliated Hospital of Xuzhou Medical University were selected as the gastric cancer group,and 204 healthy people who underwent physical examination in the hospital at the same time were selected as the control group to analyze the differences between the two groups of UA and Cys C,as well as the cor-relation between clinical pathological data and the levels of UA and Cys C.Results The levels of UA and Cys C in gas-tric cancer group were significantly higher than those in healthy control group.There were statistically significant differ-ences in lymph node metastasis,nerve or vascular invasion,differentiation degree and TNM stage between UA increased group and UA decreased group,Cys C increased group and Cys C decreased group(P<0.05).The lymph node metas-tasis rate of patients with gastric cancer in the group of UA increase+Cys C increase was significantly higher than that in the group of UA decrease+Cys C increase and the group of UA decrease+Cys C decrease(P<0.001).UA was positively correlated with Cys C(r=0.534,P<0.001).Conclusion The increase of UA and Cys C in patients with gastric cancer suggests that the lower degree of differentiation,the easier lymph node metastasis and nerve or vascular invasion,the later TNM stage,the worse prognosis.
关键词
胃癌/尿酸/胱抑素C/淋巴结转移Key words
Gastric cancer/Uric acid/Cystatin C/Lymph node metastasis引用本文复制引用
出版年
2024
NETL
NSTL
万方数据