The predictive value of 25-hydroxyvitamin D,Hcy and LDL-C for colorectal adenoma
Objective To investigate the predictive value of 25-hydroxyvitamin D,homocysteine(Hcy)and low-density lipoprotein cholesterol(LDL-C)for colorectal adenoma.Methods Patients who underwent colonoscopy in the Department of Gastroenterology,People's Hospital of Xinjiang Uygur Autonomous Region from Jun.2021 to Jan.2023 were selected as the research objects.According to the results of colonoscopy and pathology results,the patients were in-cluded in the case group(189 cases)and control group(207 cases).The levels of 25-hydroxyvitamin D,Hcy,LDL-C,and three combined detection were compared between the two groups to evaluate the predictive value and critical val-ues for colorectal adenomas.Results Serum 25-hydroxyvitamin D(OR=0.940),Hcy(OR=1.057)and LDL-C(OR=1.578)were independent influencing factors for adenomatous polyps.The combined detection of 25-hydroxyvitamin D,Hcy and LDL-C had the greatest predictive value for adenomatous polyps(AUC=0.737),superior to individual or parwise detections.The cut-off values of 25-hydroxyvitamin D,Hcy and LDL-C for predicting the risk of colorectal adenoma were 23.5 ng/mL,17.5 μmol/L and 3.85 mmol/L.Conclusion Patients with 25-hydroxyvitamin D levels below 23.5 ng/mL,Hcy above 17.5 μmol/L and LDL-C above 3.85 mmol/L are considered to be at high risk of color-ectal adenomas.Combined detection of three has the highest predictive value for colorectal adenomas.
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