25羟基维生素D、Hcy和LDL-C对结直肠腺瘤的预测价值
The predictive value of 25-hydroxyvitamin D,Hcy and LDL-C for colorectal adenoma
赵洋洋 1李紫琼 1马欣 1木克热木·依明尼亚孜 1高峰1
作者信息
- 1. 新疆维吾尔自治区人民医院消化内科,新疆 乌鲁木齐 830000;新疆消化系统疾病临床医学研究中心
- 折叠
摘要
目的 探讨 25 羟基维生素 D、同型半胱氨酸(homocysteine,Hcy)和低密度脂蛋白胆固醇(low-density lipoprotein cholesterol,LDL-C)对结直肠腺瘤的预测价值.方法 选取 2021 年 6 月至 2023 年 1 月于新疆维吾尔自治区人民医院消化内科住院行结肠镜检查的患者为研究对象,将患者依据结肠镜检查及病理结果纳入病例组(189 例)和对照组(207 例),检测并比较两组间 25 羟基维生素 D、Hcy、LDL-C 水平,以及三者联合检测对结直肠腺瘤的预测价值.结果 血清 25 羟基维生素 D(OR=0.940)、Hcy(OR=1.057)和LDL-C(OR=1.578)均为腺瘤性息肉的独立影响因素,25 羟基维生素D、Hcy和LDL-C三者联合检测对腺瘤性息肉的预测价值最大(AUC=0.737),优于单独检测及两两联合检测.25 羟基维生素 D、Hcy、LDL-C预测合并结直肠腺瘤风险的临界值分别为23.5 ng/mL、17.5 μmol/L、3.85 mmol/L.结论 25 羟基维生素 D 水平低于 23.5 ng/mL、Hcy 高于 17.5 μmol/L、LDL-C 水平高于3.85 mmol/L的患者属于合并结直肠腺瘤的高风险人群,三者联合检测对结直肠腺瘤的预测价值最大.
Abstract
Objective To investigate the predictive value of 25-hydroxyvitamin D,homocysteine(Hcy)and low-density lipoprotein cholesterol(LDL-C)for colorectal adenoma.Methods Patients who underwent colonoscopy in the Department of Gastroenterology,People's Hospital of Xinjiang Uygur Autonomous Region from Jun.2021 to Jan.2023 were selected as the research objects.According to the results of colonoscopy and pathology results,the patients were in-cluded in the case group(189 cases)and control group(207 cases).The levels of 25-hydroxyvitamin D,Hcy,LDL-C,and three combined detection were compared between the two groups to evaluate the predictive value and critical val-ues for colorectal adenomas.Results Serum 25-hydroxyvitamin D(OR=0.940),Hcy(OR=1.057)and LDL-C(OR=1.578)were independent influencing factors for adenomatous polyps.The combined detection of 25-hydroxyvitamin D,Hcy and LDL-C had the greatest predictive value for adenomatous polyps(AUC=0.737),superior to individual or parwise detections.The cut-off values of 25-hydroxyvitamin D,Hcy and LDL-C for predicting the risk of colorectal adenoma were 23.5 ng/mL,17.5 μmol/L and 3.85 mmol/L.Conclusion Patients with 25-hydroxyvitamin D levels below 23.5 ng/mL,Hcy above 17.5 μmol/L and LDL-C above 3.85 mmol/L are considered to be at high risk of color-ectal adenomas.Combined detection of three has the highest predictive value for colorectal adenomas.
关键词
结直肠腺瘤/25羟基维生素D/同型半胱氨酸/低密度脂蛋白胆固醇Key words
Colorectal adenoma/25-hydroxyvitamin D/Homocysteine/Low-density lipoprotein cholesterol引用本文复制引用
基金项目
自治区科技支疆项目(2022E02041)
新疆维吾尔自治区自然科学基金(2021D01C149)
出版年
2024
NETL
NSTL
万方数据