Analysis of the screening status of hepatitis D virus HDV-IgM and clinical character-istics of infected patients
Objective To comprehend the screening of hepatitis D virus infection in the hepatitis B population and the clinical characteristics of infected patients.Methods The results of hepatitis D infection screening(HDV-IgM)in pa-tients with hepatitis B virus infection(HBsAg positive)were retrospectively analyzed in our hospital from Jan.2014 to Oct.2023.The change of screening proportion and the clinical situation of positive results were analyzed.The clinical da-ta of patients with hepatitis D infection(HDV-IgM positive)were compared with the data in hepatitis B patients with HDV-IgM negative.The clinical characteristics of patients with hepatitis D infection were summarized.Results In recent 10 years,the average screening proportion of HDV-IgM among hepatitis B infected patients was only 3.60%(18 533/514 271).The highest screening proportion was 6.67%(3 407/51 073)in 2014,and the lowest screening proportion was 1.84%(855/46 413)in 2020.The screening proportion showed a decreasing trend from 2014 to 2020 and gradually in-creased from 2021 to 2023.There were 45 HDV-IgM positive patients,including 23 males and 22 females with ages ran-ging from(43.31±13.59)years old(1-80 years old).There was a patient with negative hepatitis B virus(both HBsAg and HBV DNA were negative).Regional distribution:27 cases(60.00%)international individuals(mainly from Mongo-lia)residing in Beijing;11 cases(24.44%)in Inner Mongolia Autonomous Region;4 cases(8.89%)in Beijing;2 cases(4.44%)in Hebei Province;1 case(2.22%)occurred in Henan Province.Compared with the HDV-IgM negative group,the HBeAg positive rate in the HDV-IgM positive group was significantly lower(P=0.001),and the ALT,AST,GGT levels were higher(all P<0.001).The distribution of the five patterns of hepatitis B differed significantly between HDV-IgM positive and negative groups was regions(P<0.05).Conclusion In recent 10 years,the screening rate of hepatitis D has been low,and the positive rate is not high.Regions with high incidence rates should focus on HDV screening to im-prove diagnostic rates.HDV infection can exacerbate the severity of hepatitis and warrant attention.
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万方数据
