肝胆损伤后胆管反应的调控机制及标志物的研究现状
Research status of regulation mechanism and related markers of ductular reaction after hepatobiliary injury
柏承志 1官敏 1汤善宏2
作者信息
- 1. 西部战区总医院消化内科,四川 成都 610083;西南交通大学医学院
- 2. 西部战区总医院消化内科,四川 成都 610083
- 折叠
摘要
胆管反应存在于多种肝胆损伤疾病中,并在其预后与疾病进展方面具有独特的临床意义.当前的研究多集中于胆管反应的发生与调控机制,这将有助于我们更好地理解胆管反应的临床意义并挖掘更多的治疗靶点.此外,胆管反应相关标志物在预测疾病预后与进展方面也具备一定作用,但目前对此的关注相对较少.本文旨在总结近年来在胆管反应调控机制方面的研究进展并提出当前对胆管反应相关标志物的研究现状.
Abstract
Ductular reaction exists in a variety of hepatobiliary injury diseases,and has unique clinical significance in its prognosis and disease progression.Current research focuses on the occurrence and regulation mechanism of ductu-lar reaction,which will help us better understand the clinical significance of ductular reaction and explore more thera-peutic targets.In addition,ductular reaction-related markers also play a role in predicting the prognosis and progression of the disease,but relatively little attention has been paid to this.This paper aimed to summarize the research progress in the regulation mechanism of ductular reaction in recent years and propose the current research status of ductular reaction-related markers.
关键词
胆管反应/肝祖细胞/胆管上皮细胞/生物标记Key words
Ductular reaction/Hepatic progenitor cells/Biliary epithelial cells/Biomarkers引用本文复制引用
基金项目
四川省中医药局科学技术研究专项(2023MS458)
出版年
2024
NETL
NSTL
万方数据