Value of ctDNA detection in the diagnosis and efficacy prediction of gastric cancer
Circulating tumor DNA(ctDNA)originates from tumor cells and can comprehensively reflect the tumor burden in cancer patients.Compared to the sampling bias of tumor tissue biopsy,plasma ctDNA can promptly reflect the overall molecular changes in cancer patients.Currently,there are two common methods for detecting ctDNA mutations.One method uses a high-frequency mutation gene panel for targeted capture to analyze ctDNA mutations in the absence of tumor tissue.The other method involves tumor tissue sequencing,selecting mutations,and designing a personalized panel that tracks ctDNA mutations and assesses tumor burden,specifically detecting tumor-specific mutations.ctDNA detec-tion plays a crucial role in the early diagnosis,treatment evaluation,and prognosis prediction of gastric cancer.On one hand,the characteristics of ctDNA in gastric cancer patients can be used for diagnosis,and on the other hand,ctDNA mutation detection can evaluate minimal residual disease in cancer patients,predict recurrence and prognosis,stratify patients,and identify those who need further treatment.In summary,this article summarized the application of ctDNA detection in the diagnosis and efficacy prediction of gastric cancer.
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