Effects of coenzyme Q10 supplementation on lipid profiles and liver enzymes of non-alcoholic fatty liver disease patients:a systematic review and Meta-analysis of ran-domized controlled trials
Objective To systematically evaluate the effects of coenzyme Q10(CoQ10)on blood lipids profiles and liver enzymes in patients with non-alcoholic fatty liver disease(NAFLD).Methods PubMed,EmBase,Cochrane Li-brary,Web of Science,Proquest,Scopus,CNKI,SinoMed,WanFang Data and VIP were searched to collect randomized controlled trials(RCTs)assessing the impact of CoQ10 on blood lipids and liver enzymes in NAFLD patients.Two review-ers screened articles,extracted data and assessed the risk of bias of included studies according to predefined criteria.Meta-analysis was conducted by using RevMan 5.3 software.Results A total of 7 RCTs involving 374 patients were included.Meta-analysis showed that compared to placebo,CoQ10 treatment didn't significantly reduce the blood lipid indexes of TC,LDL-C,HDL-C and liver enzyme indexes ALT and GGT levels in NAFLD patients treated with CoQ10,but TG and AST significantly decreased.Sensitivity analysis showed that GGT decreased significantly after excluding some studies.Subgroup analysis showed significant difference based on CoQ10 dose for TC,TG and ALT,and also a significant decrease in TG and ALT based on the duration of the intervention.No publication bias was observed among the studies.Conclusion The levels of TG and AST in NAFLD patients are significantly decreased,and the other blood lipid and liver enzyme indexes are not significantly decreased.However,sensitivity analysis and subgroup analysis showed that CoQ10 has a significant effect on TC,TG and ALT under certain conditions.Due to the quality and quantity of the included stud-ies,more rigorous multi-center,large sample,double-blind,RCTs are still needed for further verification.
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