Nrf2在溃疡性结肠炎中的研究进展
Advances in research on Nrf2 in ulcerative colitis
彭帅 1沈磊 1王文娟 1罗和生1
作者信息
- 1. 武汉大学人民医院消化内科,湖北武汉 430060;消化系统疾病湖北省重点实验室
- 折叠
摘要
溃疡性结肠炎(ulcerative colitis,UC)是一种累及结直肠黏膜及黏膜下层为主的慢性炎症性肠道疾病,近年来其发病率呈上升趋势.核因子红细胞2相关因子2(nuclear factor erythroid 2-related factor 2,Nrf2)作为调节抗氧化应激的关键转录因子,在诱导机体的抗氧化应激及抑制炎症反应中发挥着重要作用.多项研究证实,Nrf2通路参与维持肠道的正常功能、UC的发生发展及与UC相关的肠道纤维化和癌变;同时,以Nrf2信号通路为靶点的治疗药物被广泛研究.本文就Nrf2信号通路在UC中的研究进展作一综述.
Abstract
Ulcerative colitis(UC)is a chronic inflammatory bowel disease that primarily affects the mucosa and sub-mucosa of the colon,and its incidence has been on the rise in recent years.Nuclear factor erythroid 2-related factor 2(Nrf2),a key transcription factor regulating antioxidant stress,plays an important role in inducing anti-oxidative stress and suppressing inflammatory responses in the body.Multiple studies have confirmed that the Nrf2 pathway is involved in maintaining the normal function of the intestine,the occurrence and development of UC,and intestinal fibrosis and carcinogenesis associated with UC.Meanwhile,therapeutic drugs targeting the Nrf2 signaling pathway have been exten-sively studied.This article summarized the research progress of the Nrf2 signaling pathway in UC.
关键词
Nrf2/溃疡性结肠炎/氧化应激/肠道纤维化/结肠癌Key words
Nrf2/Ulcerative colitis/Oxidative stress/Intestinal fibrosis/Colorectal cancer引用本文复制引用
基金项目
湖北省自然科学基金(2022CFB136)
出版年
2024
NETL
NSTL
万方数据