Progress in investigating the mechanism of endoplasmic reticulum stress on NAFLD
The prevalence of non-alcoholic fatty liver disease(NAFLD)is increasing year by year,combined with various diseases.It have found that the progression of NAFLD is closely related to endoplasmic reticulum stress(ERS).The ERS is a self-regulatory mode in which the body can mediate misfolded proteins to maintain a stable cell state,and proper ERS contributes to cell homeostatic regulation.However,under long-term stimulation,it can cause lipid metabo-lism disorder,inflammation,insulin resistance,oxidative stress and so on to participate in the process of NAFLD.This paper analyzed how ERS can interfere with lipid metabolism disorders,inflammatory response,insulin resistance,oxida-tive stress and other related processes,so as to provide some ideas for the study of NAFLD.
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