Research progress in the regulation of hepatocellular carcinoma by CD73 through tumor microenvironment
Adenosine signaling pathway is a widely existing signal regulation hub in human body,which is involved in a series of physiological processes such as energy supply of body cells.CD73 is a signaling protein in purine adeno-sine pathway,and its role in tumor development and prognosis has attracted more and more attention in recent years,es-pecially in hepatocellular carcinoma(HCC).CD73 plays an important role in the occurrence,development and metas-tasis of liver cancer in the tumor microenvironment.This paper focused on reviewing the mechanism of action of CD73-mediated adenosine signaling pathway in the progression of primary liver cancer in the tumor microenvironment,and summarized CD73 as a potential therapeutic target for liver cancer,providing new insights for the clinical diagnosis and treatment of HCC.
NETL
NSTL
万方数据
