The significance and correlation analysis of folate receptor positive circulating tumor cells in patients with gastric cancer
Objective To explore the clinical significance of folate receptor positive circulating tumor cells(FR+CTC)in patients with gastric cancer.Methods A retrospective analysis the clinical data of gastric cancer surgery patients who had preoperative detection of FR+CTC expression.ROC curves were drawn for FR+CTC,albumin,total protein,hemoglobin,CA125,CA199 and CEA to predict peritoneal metastasis,lymph node metastasis,vascular invasion,nerve invasion,tumor breakthrough serosal and advanced gastric cancer in patients.The correlation between FR+CTC values and gastrointestinal tumor markers and commonly used clinical nutritional indicators was investigated.The statistical difference in the expression of FR+CTC values and clinical related indicators in different types of gastric cancer was explored.Results The AUC values of FR+CTC in diagnosing peritoneal metastasis,lymph node metastasis,vascular invasion,nerve invasion,tumor break-through serosal and stage Ⅲ-Ⅳ gastric cancer were 0.933,0.653,0.614,0.628,0.714 and 0.703,respectively,which were significantly better than traditional tumor markers(CEA,CA199,CA125).Through Spearman correlation analysis,the FR+CTC value was negatively correlated with albumin content,with a correlation coefficient(R=-0.26,P=0.0043).The ex-pression of FR+CTC in patients with peritoneal metastasis,lymph node metastasis,vascular invasion,nerve invasion,tumor breakthrough serosal and stage Ⅲ-Ⅳ gastric cancer was significantly increased,and the difference was statistically significant.Conclusion The FR+CTC value can more accurately predict the probability of gastric cancer patients with peritoneal metas-tasis,lymph node metastasis,vascular invasion,nerve invasion,tumor breakthrough serosal and tumors in stage Ⅲ-Ⅳ.More-over,the expression of FR+CTC in these types of gastric cancer patients is significantly increased,which can be routinely used as a new type of clinical tumor marker.
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