Changes of serum IL-26 and 25(OH)D levels in patients with chronic hepatitis C and its clinical significance
Objective To investigate the changes of serum IL-26,25(OH)D levels in patients with chronic hepati-tis C(CHC)and its clinical significance.Methods A total of 120 patients with CHC admitted to our hospital from Jan.2022 to Jan.2023 were selected as the study group,and 50 healthy subjects in No.987 Hospital of Joint Logistics Support Force of Chinese People's Liberation Army at the same time were selected as the control group.Results Com-pared with the control group,the levels of IL-26 and 25(OH)D were increased in the study group(P<0.05).Com-pared with F0-F1,serum IL-26 and 25(OH)D levels in CHC patients with F2-F3 classification were increased and de-creased,with statistical significance(P<0.05).Compared with F2-F3,serum IL-26 and 25(OH)D levels in CHC pa-tients with F4 classification were increased(P<0.05).Compared with the high viral load group,the serum IL-26 and 25(OH)D levels of CHC patients in the low viral load group were decreased(P<0.05).After treatment,IL-26 levels were decreased while 25(OH)D levels were increased in CHC patients,respectively(P<0.05).Compared with CHC patients with poor prognosis,serum IL-26 level was decreased and 25(OH)D level was increased in CHC patients with non-poor prognosis,and the difference was statistically significant(P<0.05).IL-26 and 25(OH)D were negatively corre-lated in patients with CHC(r=-0.766,P<0.001).Conclusion Serum IL-26 and 25(OH)D levels in patients with chronic C viral hepatitis are elevated and correlated with the degree of liver fibrosis and HCV viral load.Post-clinical treatment,this phenomenon can be reversed.
NETL
NSTL
万方数据
