Clinical study of bleomycin iodized oil emulsion combined with gelatin sponge gran-ules in transcatheter arterial embolization treatment of hepatic hemangioma
Objective To investigate the clinical effect of bleomycin iodized oil emulsion combined with gelatin sponge granule in transcatheter arterial embolization(TAE)of hepatic hemangioma and its influence on complication rate.Methods A total of 80 patients with hepatic hemangioma diagnosed and treated in the Department of Interventional Medicine of our hospital from Aug.2015 to Dec.2021 were selected as subjects.All patients received TAE treatment and were randomly divided into two groups with 40 cases in each group.The control group was treated with bleomycin io-dized oil emulsion,and the observation group was treated with gelatine sponge granules.The two groups completed 6 months of outpatient follow-up after treatment.The surgical response rate,surgical indexes,liver and kidney function,to-tal bile acid,hemangioma size and postoperative complication rate were compared between the two groups.Results Six months after operation,the effective rate of observation group(97.50%)was higher than that of control group(85.00%)(P<0.05).Tumor diameter was decreased 6 months after operation in both groups.The tumor diameter of observation group was lower than that of control group(P<0.05).There were no statistical differences in the levels of Scr,BUN,ALT,AST between the two groups before and 6 months after surgery(P>0.05).The TBA levels in both groups before surgery were lower than that 6 months after surgery(P<0.05),and the TBA level in the observation group was lower than that in the control group 6 months after surgery(P<0.05).There were no statistical differences in perioperative fever,postoperative infection,hepatic pain,biliary reflex,nausea and vomiting between the two groups(P>0.05).Conclusion Bleomycin iodized oil emulsion combined with gelatin sponge granules in hepatic hemangioma TAE patients can achieve a higher effective rate,less surgical trauma,little influence on the liver and kidney function of patients,can improve the level of total bile acid,can reduce the size of hemangioma,and does not increase the inci-dence of postoperative complications,worthy of clinical application.
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