溃疡性结肠炎(ulcerative colitis,UC)是一类病因和发病机制尚不明确的慢性、反复发作性疾病,主要累及结直肠,但有近端进展甚至累及全结肠的趋势.15%～20%的 UC 患者在其疾病进程中因急性重度溃疡性结肠炎(acute severe ulcerative colitis,ASUC)住院治疗,治疗困难,往往需要运用生物制剂、全结肠切除术等,严重增加了不良预后.故而临床上对于预测 ASUC 的发生发展有潜在的客观需求.本文对能够预测 ASUC发生及发展的相关风险因子进行综述.
Research progress on risk factors for predicting the occurrence and progression of acute severe ulcerative colitis
Ulcerative colitis(UC)is a chronic,recurrent disease with unclear etiology and pathogenesis,mainly in-volving the colorectal,but with a tendency to proximal progression and even involvement of the whole colon.About 15%-20%of UC patients are hospitalized for acute severe ulcerative colitis(ASUC)during the course of their disease.The treatment is difficult and often requires the use of biologics and pancolectomy,which seriously increases the poor prognosis.Therefore,there is a potential objective demand for predicting the occurrence and progression of ASUC in clinical practice.This article reviewed the risk factors that can predict the occurrence and progression of ASUC.
Ulcerative colitisAcute severe ulcerative colitisDisease severityDisease progressionPredictor
NETL
NSTL
万方数据
