预测急性重度溃疡性结肠炎发生发展的相关风险因子研究进展
Research progress on risk factors for predicting the occurrence and progression of acute severe ulcerative colitis
陈洁 1张红杰 2焦春花 2张悦 1任天棋 1徐晨静 3许莹 3蒋文瑜4
作者信息
- 1. 苏北人民医院消化内科,江苏 扬州 225001
- 2. 南京医科大学第一附属医院消化内科
- 3. 南京市第一医院消化内科
- 4. 江苏省中医院消化内镜中心
- 折叠
摘要
溃疡性结肠炎(ulcerative colitis,UC)是一类病因和发病机制尚不明确的慢性、反复发作性疾病,主要累及结直肠,但有近端进展甚至累及全结肠的趋势.15%～20%的 UC 患者在其疾病进程中因急性重度溃疡性结肠炎(acute severe ulcerative colitis,ASUC)住院治疗,治疗困难,往往需要运用生物制剂、全结肠切除术等,严重增加了不良预后.故而临床上对于预测 ASUC 的发生发展有潜在的客观需求.本文对能够预测 ASUC发生及发展的相关风险因子进行综述.
Abstract
Ulcerative colitis(UC)is a chronic,recurrent disease with unclear etiology and pathogenesis,mainly in-volving the colorectal,but with a tendency to proximal progression and even involvement of the whole colon.About 15%-20%of UC patients are hospitalized for acute severe ulcerative colitis(ASUC)during the course of their disease.The treatment is difficult and often requires the use of biologics and pancolectomy,which seriously increases the poor prognosis.Therefore,there is a potential objective demand for predicting the occurrence and progression of ASUC in clinical practice.This article reviewed the risk factors that can predict the occurrence and progression of ASUC.
关键词
溃疡性结肠炎/急性重度溃疡性结肠炎/疾病严重程度/疾病进展/预测因子Key words
Ulcerative colitis/Acute severe ulcerative colitis/Disease severity/Disease progression/Predictor引用本文复制引用
基金项目
国家自然科学基金(82370535)
国家自然科学基金(82070568)
出版年
2024
NETL
NSTL
万方数据