Research progress on signal pathways associated with serrated lesions of colorectal and its association with Fusobacterium nucleatum
The morbidity and mortality of colorectal cancer(CRC)have been increasing year by year,affecting the public health.The serrated pathway is one of the important pathways of CRC and plays a significant role in the progression of CRC.Among them,serrated lesions have a low detection rate due to the lack of unified pathological diagnostic criteria before 2010,their easy oversight during endoscopy,and the potenital confusion with non-malignant polyps.However,they are prone to progress into right side colon cancer with BRAF mutation,CpG island methylation phenotype and microsatel-lite instability,often diagnosed at an advanced stage with poor prognosis,making them a recent research hotspot.In recent years,studies on microbiata-inducted CRC have become a hot topic.It has been reported that Fusobacterium nucleatum is one of the important microorganisms promoting CRC.Studies have shown that Fusobacterium nucleatum promotes the pro-gression of serrated lesions through inflammatory pathways.Research on the impact of Fusobacterium nucleatum on serrated lesions in the inflammatory signaling pathway can guide prognosis and treatment decisions for the disease.
Serrated lesionFusobacterium nucleatumInflammatory pathways and related genes
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