脂质代谢紊乱在非酒精性脂肪性肝病中的作用概述
The role of lipid metabolism disorders in non-alcoholic fatty liver disease
谭明 1张慧 1任吉华 1程胜桃 1陈娟2
作者信息
- 1. 重庆医科大学 感染性疾病分子生物学教育部重点实验室,重庆 400016
- 2. 重庆医科大学 感染性疾病分子生物学教育部重点实验室,重庆 400016;重庆医科大学 临床检验诊断学教育部重点实验室,重庆 400016
- 折叠
摘要
非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)是一组因肝细胞内脂质过度积聚引起的肝脏疾病,可进一步发展为肝硬化或肝细胞癌等终末期肝病.由于 NAFLD的确切发病机制尚未明确,全球范围内尚无针对 NAFLD 的治疗药物获批上市.因此,阐明 NAFLD发生的分子机制,揭示脂质代谢在 NAFLD 发生发展中的重要作用,将有利于开发新的 NAFLD 治疗靶点.因此,本文对脂质代谢紊乱与 NAFLD的研究现状进行了综述,试图为解析 NAFLD发病机制以及寻找治疗靶点提供理论依据.
Abstract
Non-alcoholic fatty liver disease(NAFLD)is a series of liver diseases caused by excessive accumulation of lipids in the liver,which can progress to end-stage liver disease such as cirrhosis or hepatocellular carcinoma.As the exact pathogenesis of NAFLD is not yet understood,no drug specific for NAFLD has been approved by Food and Drug Administration.Nevertheless,elucidating the molecular mechanism of NAFLD occurrence and revealing the important role of lipid metabolism in the occurrence and development of NAFLD will be conducive to the development of new thera-peutic targets for NAFLD.Therefore,this work reviewed the current research status of lipid metabolism disorders and NAFLD,in an attempt to provide theoretical basis for the analysis of the pathogenesis of NAFLD and the search for ther-apeutic targets.
关键词
非酒精性脂肪性肝病/脂质代谢/游离脂肪酸/胰岛素抵抗Key words
Non-alcoholic fatty liver disease/Lipid metabolism/Free fatty acids/Insulin resistance引用本文复制引用
基金项目
国家自然科学基金面上项目(82273423)
国家自然科学基金青年基金(82202501)
出版年
2024
NETL
NSTL
万方数据