Advance in the research of metabolites of intestinal flora in non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease(NAFLD)is a liver metabolic disease characterized by lipid accumula-tion in liver cells greater than 5%of liver weight.It can progress from simple fatty liver to nonalcoholic steatohepatitis,fibrosis,cirrhosis and hepatocellular carcinoma.NAFLD is often associated with metabolic dysfunction such as over-weight or obesity,type 2 diabetes and insulin resistance.In recent years,a variety of bioactive metabolites produced by intestinal flora are found associated with the onset and progression of NAFLD.With the deepening of research,more gut-derived metabolites have been identified,such as short-chain fatty acids,secondary bile acids,indole-3-propionic acid,choline and its metabolites,ethanol,imidazole propionate,endotoxin,etc.These gut-derived metabolites play an im-portant role in hepatic fat accumulation,inflammatory damage and oxidative stress,fibrosis,and may also be potential therapeutic targets with clinical value.
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